Ofloxacin: in vitro and in vivo activity

Ofloxacin is a new oral antibacterial fluoro-quinolone, endowed with potent bactericidal activity over a very broad bacterial spectrum. Ofloxacin's minimum bactericidal concentration (MBC) proved to be equal to the minimum inhibitory concentration (MIC) even at high inocula or in the presence of human serum with a high bactericidal rate. The effect of the presence of urine was that the bacteria were sensitive to higher drug concentrations, as in the case of other quinolones; these concentrations, however, are easily reached in the urinary tract after a single therapeutic dose in man. Ofloxacin proved to be extremely effective in curing experimental infections induced by both gram-positive and gram-negative pathogens.