Covalent organic framework based nanoagent for enhanced mild-temperature photothermal therapy
Qiaoqiao Sun1, Kun Tang1, Liqun Song1
1College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, P. R. China. lina@sdnu.edu.cn.
Biomaterials Science
|October 28, 2021
Summary
A novel nanoagent, COF-GA, enhances mild photothermal therapy by inhibiting HSP90, effectively suppressing tumor growth with minimal damage to healthy tissues.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Photothermal therapy (PTT) uses laser-induced hyperthermia to ablate tumors.
- High temperatures in PTT can cause collateral damage to surrounding healthy tissues.
- Developing low-temperature PTT is crucial for minimizing side effects.
Purpose of the Study:
- To design a nanoagent for enhanced, low-temperature photothermal therapy.
- To inhibit Heat Shock Protein 90 (HSP90) to overcome tumor heat resistance.
- To investigate the antitumor efficacy of the COF-GA nanoagent in vivo.
Main Methods:
- Synthesis of a nanoagent, COF-GA, combining covalent organic frameworks (COFs) and gambogic acid (GA).
- Evaluation of COF-GA's photothermal properties under laser irradiation.
- Assessment of COF-GA's efficacy in inhibiting HSP90 and its antitumor effects in vivo.
Main Results:
- COF-GA effectively increased tumor temperature under laser irradiation.
- The nanoagent significantly suppressed tumor growth in vivo.
- Mild-temperature PTT with COF-GA demonstrated excellent antitumor efficacy and reduced damage to normal tissues.
Conclusions:
- COF-GA is a promising nanoagent for mild-temperature photothermal therapy.
- Inhibiting HSP90 enhances PTT efficacy at lower temperatures.
- This approach offers a safer and more effective cancer treatment strategy.
