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A Method for Measuring the Surface Free Energy of Topical Semi-solid Dosage Forms
Kaname Hashizaki1, Yuto Hoshii1, Kosuke Ikeuchi1
1Laboratory of Physical Chemistry, School of Pharmacy, Nihon University.
Chemical & Pharmaceutical Bulletin
|November 1, 2021
Summary
This study establishes a reproducible method to measure the surface free energy (SFE) of semi-solid dosage forms (SSDFs) using contact angle measurements. The calculated SFE values correlate with the physicochemical properties of the SSDFs.
Area of Science:
- Physical Chemistry
- Pharmaceutical Sciences
- Materials Science
Background:
- Surface free energy (SFE) is a critical parameter influencing the performance and application of semi-solid dosage forms (SSDFs).
- Accurate and reproducible measurement of SFE for SSDFs is challenging due to their complex composition and physical state.
Purpose of the Study:
- To develop and validate a reproducible method for determining the surface free energy (SFE) of various semi-solid dosage forms (SSDFs).
- To calculate the SFE and its components for different SSDFs and correlate them with their physicochemical properties.
- To determine the work of adhesion (WA) of SSDFs to skin.
Main Methods:
- Four types of SSDFs (petrolatum, O/W cream, W/O cream, alcohol-based gel) were prepared and spread on glass slides.
- Contact angles were measured using four test liquids (water, glycerol, diiodomethane, n-hexadecane) immediately after application to capture initial interactions.
- The Owens-Wendt-Rabel-Kaelble equation was employed to calculate SFE from the obtained contact angle data.
Main Results:
- A reproducible method for measuring contact angles and determining SFE of SSDFs was established.
- Calculated SFE values accurately reflected the inherent physicochemical properties of the tested SSDFs.
- Work of adhesion (WA) values for all tested SSDFs against micropig skin were found to be comparable.
Conclusions:
- The developed contact angle measurement technique provides a reliable method for assessing the SFE of SSDFs.
- The SFE is a valuable descriptor of SSDF physicochemical characteristics.
- The comparable work of adhesion suggests similar interactions between various SSDFs and skin.
Keywords:
Owens–Wendt–Rabel–Kaelble methodYucatan micropigcontact anglesemi-solid dosage formsurface free energyMore Related Videos
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