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Depression and Inflammatory Markers in Veterans With Multiple Sclerosis
Pamela Newland1, Yelyzaveta Basan1, Ling Chen2
132989Goldfarb School of Nursing at Barnes-Jewish College, Saint Louis, MO, USA.
Biological Research for Nursing
|November 1, 2021
Summary
In multiple sclerosis (MS), the anti-inflammatory cytokine IL-10 was linked to lower depression levels in veterans. This finding may help understand MS-related depression and inform care.
Area of Science:
- Neuroimmunology
- Central Nervous System (CNS) Disorders
Background:
- Multiple sclerosis (MS) is an inflammatory neurodegenerative disease affecting the CNS.
- MS impacts quality of life and is associated with depression.
- Biological mechanisms linking MS depression and inflammation require further elucidation.
Purpose of the Study:
- To investigate the relationship between salivary cytokine levels and depression in veterans with MS.
- To explore cytokines as potential biomarkers for MS-related depression.
Main Methods:
- A pilot study measured salivary levels of interleukin (IL)-6, IL-1beta (β), and IL-10 in 24 veterans with MS.
- Descriptive statistics and Pearson correlation coefficients were used to analyze the data.
Main Results:
- The anti-inflammatory cytokine IL-10 showed a significant negative association with depression scores (r = -0.47, p = .024).
Conclusions:
- Salivary IL-10 may be a useful indicator for understanding depression in MS.
- Cytokine analysis offers a promising approach for identifying biological mechanisms underlying MS-related depression.
- Findings may assist nurses in caring for veterans with MS.
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