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Updated: Oct 14, 2025

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

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Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study.

Zahra Khodabakhshi^1,2, Nazanin Hosseinkhah³, Hossein Ghadiri^4,5

¹MSc, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Science, Tehran, Iran.

Journal of Biomedical Physics & Engineering

|November 1, 2021

Summary

This study simulated microbubble behavior in elastic microvessels under ultrasound. Softer, larger microbubbles are ideal for therapeutic applications, reducing required acoustic pressure and frequency for desired effects.

Keywords:

Blood-Brain-Barrier Microbubbles Shear Stress Therapeutics Ultrasound

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Area of Science:

Biomedical Engineering
Acoustic Physics
Computational Modeling

Background:

Microbubbles are established diagnostic ultrasound contrast agents.
Emerging therapeutic uses include drug delivery and blood-brain barrier opening.
Ultrasound-activated microbubble oscillations induce mechanical stresses on vessel walls, with potential for both benefit and damage.

Purpose of the Study:

To simulate microbubble-ultrasound interactions within elastic microvessels.
To investigate parameters influencing microstreaming-induced shear stress on vessel walls.

Main Methods:

A 2D finite element simulation approach was employed.
Investigated acoustical and bubble material parameters affecting microbubble dynamics and wall stress.

Main Results:

Maximum shear stress remained below 4 kPa within therapeutic acoustic parameter ranges.
Shear stress was largely independent of shell viscosity but decreased with increased shell stiffness.
Increasing acoustic pressure led to a higher shear stress.

Conclusions:

Bubble properties significantly impact behavior alongside acoustic parameters.
Softer, larger microbubbles are more suitable for therapeutic applications.
These optimized bubbles can achieve therapeutic effects at lower frequencies and acoustic pressures.