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Related Experiment Videos

[New pharmacologic developments in physical urticaria--therapeutic consequences].

M W Greaves, A Kobza Black, R M Barr

    Zeitschrift Fur Hautkrankheiten
    |February 1, 1987
    PubMed
    Summary

    Prostaglandin D2 (PGD2) is released alongside histamine in physical urticarias, suggesting a role beyond histamine in these conditions. PGD2 may play an indirect role in the development of cold and heat urticaria.

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    Unmet clinical needs in chronic spontaneous urticaria. A GA²LEN task force report.

    Allergy·2010

    Area of Science:

    • Immunology
    • Dermatology
    • Allergy

    Context:

    • Physical urticarias involve mast cell mediators beyond histamine.
    • Previous studies identified neutrophil and eosinophil chemotactic factors and platelet-activating factor-like lipids in cold urticaria.
    • The role of prostaglandin D2 (PGD2) in physical urticaria pathogenesis requires further elucidation.

    Purpose:

    • To investigate the involvement of prostaglandin D2 (PGD2) in the pathogenesis of physical urticarias.
    • To quantify PGD2 levels in response to cold and heat challenges in patients with urticaria.
    • To assess the effect of combined treatment on PGD2 and histamine release.

    Summary:

    • An increase in prostaglandin D2 (PGD2) was measured in venous blood draining cold-challenged areas in patients with idiopathic cold contact urticaria.

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  • PGD2 release paralleled histamine release and the urticarial reaction's onset, development, and subsidence, with no direct quantitative relationship observed.
  • Similar increases in histamine and PGD2 occurred during heat challenge in localized heat urticaria, significantly reduced by combined tolerance induction and indomethacin treatment, suggesting an indirect role for PGD2.

    • Impact:

    • This study highlights prostaglandin D2 (PGD2) as a significant mediator in physical urticarias, alongside histamine.
    • Findings suggest PGD2 may play an indirect role in the pathogenesis of cold and heat urticaria.
    • The results provide a basis for exploring novel therapeutic strategies targeting PGD2 pathways in physical urticaria treatment.