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Related Experiment Video

Updated: Oct 14, 2025

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Published on: June 27, 2025

Placenta Accreta Spectrum.

Bridget M Donovan^1,2, Scott A Shainker^1,2

¹Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, MA.

|November 2, 2021

Summary

This summary is machine-generated.

Placenta accreta spectrum (PAS) is increasing due to factors like C-sections. Early diagnosis and planned delivery improve maternal and fetal outcomes for this complex condition.

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Area of Science:

Obstetrics and Gynecology
Maternal-Fetal Medicine

Background:

Placenta accreta spectrum (PAS) encompasses conditions of abnormal placental adherence to the uterine wall.
Rising incidence is linked to increased cesarean deliveries and assisted reproductive technologies.
PAS poses significant maternal risks (hemorrhage, hysterectomy, death) and neonatal risks (preterm birth).

Purpose of the Study:

To review the current understanding of placenta accreta spectrum (PAS).
To highlight diagnostic challenges and management strategies for PAS.
To identify knowledge gaps in PAS pathophysiology, diagnosis, and treatment.

Main Methods:

Review of existing literature on placenta accreta spectrum.
Analysis of diagnostic modalities including ultrasonography and MRI.
Evaluation of management strategies, including expectant management and planned preterm delivery.

Main Results:

Antenatal diagnosis, though imperfect, significantly improves maternal outcomes compared to intrapartum diagnosis.
Planned delivery between 34-35 weeks' gestation appears to optimize maternal and fetal outcomes.
Multidisciplinary team management is the recommended approach for complex PAS cases.

Conclusions:

Despite advances, understanding of PAS pathophysiology, diagnosis, and management requires further research.
Early antenatal diagnosis and planned, multidisciplinary management are crucial for improving outcomes.
Optimizing delivery timing balances maternal and fetal risks in PAS pregnancies.