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[Research progress on the effect of selective autophagy receptor p62 on fibrotic diseases]

S Yang1, S Y Tan1, S Chen1

  • 1School of Medicine, Hunan Normal University, Changsha 410000, China.

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi = Zhonghua Laodong Weisheng Zhiyebing Zazhi = Chinese Journal of Industrial Hygiene and Occupational Diseases
|November 2, 2021
PubMed

Insights

Selective autophagy maintains cell balance. The p62 protein, an autophagy receptor, is crucial for this process and its dysfunction contributes to fibrotic diseases like lung, liver, and kidney fibrosis.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Pathology

Background:

  • Selective autophagy is essential for cellular homeostasis, clearing damaged components via autophagy receptors.
  • p62 is a key autophagy receptor protein involved in various signaling pathways.
  • Fibrosis, characterized by scarring, leads to organ dysfunction and failure in chronic inflammatory diseases.

Purpose of the Study:

  • To investigate the role of the selective autophagy receptor p62 in the development of fibrotic diseases.
  • To understand how p62 accumulation, overexpression, and ectopic expression impact lung, liver, and kidney fibrosis.

Main Methods:

  • The study focuses on the molecular mechanisms of selective autophagy and p62.
  • Analysis of p62's involvement in signaling pathways relevant to fibrosis.
  • Examination of p62's expression patterns in fibrotic conditions.

Main Results:

  • p62 plays a significant role in selective autophagy.
  • Accumulation, overexpression, and ectopic expression of p62 exacerbate lung, liver, and kidney fibrosis.
  • p62's function is critical in preventing fibrotic disease progression.

Conclusions:

  • Selective autophagy receptor p62 is a critical factor in fibrotic diseases.
  • Targeting p62 may offer therapeutic strategies for fibrotic conditions.
  • Further research into p62's role is vital for understanding and treating fibrosis.
Keywords:
FibroticKidney fibrosisLiver fibrosisLung fibroticSelective autophagyp62

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