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Related Concept Videos

Viral Recombination00:57

Viral Recombination

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Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Related Experiment Video

Updated: Oct 14, 2025

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

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[Hepatitis E as a zoonosis].

N Pavio1, C Renou2, A Boutrouille1

  • 1UMR1161 Virologie Afssa, Enva, Inra, École nationale vétérinaire d'Alfort, 7, avenue du Général-de-Gaulle, 94704 Maisons-Alfort Cedex.

Virologie (Montrouge, France)
|November 4, 2021
PubMed
Summary
This summary is machine-generated.

Hepatitis E virus (HEV) causes widespread waterborne hepatitis outbreaks in endemic areas. In non-endemic regions, understanding HEV transmission routes, especially from animal reservoirs, is crucial for public health.

Keywords:
animal reservoirhepatitis E virusspecies crossingzoonosis

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Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Context:

  • Hepatitis E virus (HEV) causes significant waterborne epidemics in endemic regions.
  • Sporadic HEV cases occur in non-endemic areas, with poorly understood transmission routes.
  • HEV is unique among hepatitis viruses for having a known animal reservoir.

Purpose:

  • To investigate the transmission pathways of Hepatitis E virus in non-endemic regions.
  • To identify potential sources of human contamination with HEV in areas where it is not typically endemic.
  • To explore the role of animal reservoirs and food products in HEV transmission to humans.

Summary:

  • HEV outbreaks are common in endemic areas via water, but transmission in non-endemic regions remains unclear.
  • Evidence suggests animal-to-human transmission of HEV, possibly through contaminated food.
  • Further research is needed to identify all human contamination sources and assess the risk posed by HEV's genetic variability.

Impact:

  • Enhancing understanding of HEV epidemiology in non-endemic settings.
  • Informing public health strategies to prevent HEV infections.
  • Guiding future research on HEV reservoirs and transmission dynamics.