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Related Concept Videos

Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
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Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

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Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
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Chemical Synapses01:26

Chemical Synapses

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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
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Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Related Experiment Video

Updated: Oct 14, 2025

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients
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Myasthenic Crisis After Recurrent COVID-19 Infection.

Adam M Spanier1, James I Gragg1

  • 1is a Resident, and is a Faculty Member, both at Carl R. Darnall Army Medical Center in Fort Hood, Texas.

Federal Practitioner : for the Health Care Professionals of the VA, Dod, and PHS
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Summary
This summary is machine-generated.

A patient with myasthenia gravis recovered from a severe COVID-19 crisis using plasmapheresis. This treatment helped manage the neuromuscular disorder exacerbated by the viral infection.

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disease.
  • COVID-19 can trigger or exacerbate autoimmune conditions.
  • Acute exacerbations of MG can lead to respiratory failure and crisis.

Purpose of the Study:

  • To report on the management of a myasthenia gravis patient experiencing an acute crisis following two COVID-19 infections.
  • To highlight the role of plasmapheresis in managing MG crisis during a pandemic.

Main Methods:

  • Case report of a myasthenia gravis patient.
  • Documentation of COVID-19 infection and subsequent myasthenic crisis.
  • Administration and monitoring of plasmapheresis therapy.

Main Results:

  • The patient survived two severe COVID-19 infections.
  • Plasmapheresis was crucial for the patient's recovery from the acute myasthenic crisis.
  • Successful management of a complex case involving autoimmune disease and viral illness.

Conclusions:

  • Plasmapheresis remains a vital therapeutic option for managing severe myasthenic crises.
  • COVID-19 can significantly worsen myasthenia gravis, necessitating prompt and aggressive treatment.
  • This case underscores the importance of considering infectious triggers in autoimmune disease exacerbations.