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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Intravenous Laser Therapy in Patients With Acute Kidney Injury: A Randomized Clinical Trial.
Mohammad Reza Razzaghi1, Esmat Ghanei2, Sheida Malekian2
1Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Journal of Lasers in Medical Sciences
|November 4, 2021
Summary
Intravascular laser irradiation of blood (ILIB) may improve recovery for acute kidney injury (AKI) patients. This study found faster reductions in neutrophil gelatinase-associated lipocalin (NGAL) levels in the ILIB group, suggesting potential benefits.
Area of Science:
- Nephrology
- Laser Therapy
- Biomarkers
Background:
- Intravascular laser irradiation of blood (ILIB) is a recognized laser therapy technique.
- Its effectiveness and safety in treating acute kidney injury (AKI) have not been previously studied.
Purpose of the Study:
- To evaluate the feasibility and outcomes of ILIB in managing AKI patients.
- To compare ILIB treatment with a Sham-laser control group.
Main Methods:
- A randomized clinical trial involving 26 intra-renal AKI patients.
- Patients were assigned to either ILIB or Sham-laser groups.
- Key parameters monitored included NGAL levels, dialysis needs, and hospitalization duration.
Main Results:
- Both groups showed significant post-treatment improvements, excluding hemoglobin.
- Neutrophil gelatinase-associated lipocalin (NGAL) levels decreased in both groups.
- The reduction in both serum and urine NGAL was statistically faster in the ILIB group.
Conclusions:
- The accelerated decline in NGAL levels in the ILIB group suggests a potential benefit for AKI recovery.
- ILIB may be a promising therapeutic option for patients with acute kidney injury.
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