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Adoptive transfer of tumor-specific Th9 cells eradicates heterogeneous antigen-expressing tumor cells
Kevin Sek1, Cheok Weng Chan1, Paul A Beavis1
1Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, VIC, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville 3010, Australia.
Abstract:
In this issue of Cancer Cell, Xue et al. demonstrate that adoptive transfer of tumor-specific Th9 cells can eradicate established tumors containing antigen-loss-variant cells (ALVs) through both direct killing and bystander effects mediated by intratumoral accumulation of extracellular ATP (eATP) that promotes monocyte infiltration and stimulation of IFNα/β production.
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