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Related Concept Videos

Asepsis01:28

Asepsis

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The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
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Hand hygiene01:23

Hand hygiene

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Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
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Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

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Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
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Pneumonia III: Complications and Assessment01:30

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Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
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Infection01:20

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
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Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

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Sepsis.

Michael H Ackerman1, Thomas Ahrens2, Justin Kelly3

  • 1Masters in Healthcare Innovation Program, The Ohio State University, Columbus, OH, USA.

Critical Care Nursing Clinics of North America
|November 7, 2021
PubMed
Summary
This summary is machine-generated.

This article reviews the historical definitions of sepsis, current understanding of its pathogenesis, and the development of treatment bundles for this critical condition.

Keywords:
ApoptosisBundlesSIRSSepsisSurviving sepsisqSOFA

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Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Pathophysiology

Background:

  • Sepsis definitions have evolved significantly over time.
  • Understanding sepsis pathogenesis is crucial for effective management.
  • Treatment protocols for sepsis have undergone continuous refinement.

Purpose of the Study:

  • To provide a historical overview of sepsis definitions.
  • To summarize the current knowledge on sepsis pathogenesis.
  • To present the evolution of sepsis treatment bundles.

Main Methods:

  • Literature review of historical and current sepsis definitions.
  • Synthesis of research on sepsis pathogenesis.
  • Analysis of the development of sepsis treatment guidelines.

Main Results:

  • The article traces the changing criteria for sepsis diagnosis.
  • It highlights key advancements in understanding the biological mechanisms of sepsis.
  • The progression of evidence-based treatment bundles is detailed.

Conclusions:

  • A comprehensive understanding of sepsis history and pathogenesis informs current treatment strategies.
  • The evolution of treatment bundles reflects ongoing efforts to improve patient outcomes in sepsis.
  • This overview serves as a valuable resource for clinicians and researchers in critical care.