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A regulatory role of circRNA-miRNA-mRNA network in osteoblast differentiation

R Mohanapriya1, R L Akshaya1, N Selvamurugan1

  • 1Department of Biotechnology, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, 603 103, Tamil Nadu, India.

Biochimie
|November 7, 2021
PubMed

Insights

This review details how circular RNAs (circRNAs) and microRNAs (miRNAs) interact with messenger RNAs (mRNAs) to regulate osteoblast differentiation, offering insights into bone health and disease.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Osteoblast differentiation is crucial for bone development and repair.
  • Dysregulation of osteoblast differentiation leads to bone diseases.
  • Non-coding RNAs (ncRNAs) are key regulators of gene expression.

Purpose of the Study:

  • To review the regulatory roles of circRNAs, miRNAs, and mRNAs in osteoblast differentiation.
  • To elucidate the circRNA-miRNA-mRNA axis in bone biology.
  • To highlight potential diagnostic and therapeutic targets for bone disorders.

Main Methods:

  • Literature review of studies on ncRNAs and osteoblast differentiation.
  • Analysis of regulatory interactions between circRNAs, miRNAs, and mRNAs.
  • Synthesis of findings on the circRNA-miRNA-mRNA axis.

Main Results:

  • circRNAs and miRNAs directly and indirectly regulate osteoblast marker gene expression.
  • Complex crosstalk exists among circRNAs, miRNAs, and mRNAs during osteoblast differentiation.
  • The circRNA-miRNA-mRNA axis is a significant regulatory network in this process.

Conclusions:

  • Understanding the circRNA-miRNA-mRNA axis is vital for comprehending osteoblast differentiation.
  • This axis presents potential therapeutic strategies for bone-related diseases.
  • Further research into these interactions can advance skeletal biology.
Keywords:
OsteoblastRunx2ncRNAs

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