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Direct and Indirect Neurological Signs of COVID-19
O A Gromova1,2, I Yu Torshin1,2, V A Semenov3
1Institute of Pharmacoinformatics, "Informatics and Control" Federal Research Center, Russian Academy of Sciences, Moscow, Russia.
Neuroscience and Behavioral Physiology
|November 9, 2021
Summary
COVID-19 can cause neurological issues, including anosmia and stroke, by affecting neurotransmitters and causing inflammation. Long-term effects may include neurodegeneration, necessitating specialized rehabilitation and specific drug therapies.
Area of Science:
- Neurology
- Infectious Diseases
- Neuroscience
Background:
- COVID-19, caused by SARS-CoV-2, presents with a wide range of neurological manifestations.
- Understanding these neurological complications is crucial for patient management and long-term care.
Purpose of the Study:
- To systematically analyze and categorize the neurological symptoms associated with COVID-19.
- To elucidate the pathophysiological mechanisms linking SARS-CoV-2 infection to neurological disorders.
Main Methods:
- A systematic computerized analysis of 2374 PubMed publications on COVID-19 neurological manifestations.
- Topological data analysis was employed to identify interactions between infection and neurological outcomes.
Main Results:
- Identified interactions between SARS-CoV-2, neurotransmitter imbalances, inflammation, and neurodegeneration.
- Common symptoms include anosmia/ageusia, ischemic stroke, encephalitis, and Guillain-Barré syndrome.
- COVID-19 exacerbates conditions like multiple sclerosis and myopathies.
Conclusions:
- COVID-19 can lead to long-term neurodegenerative changes, requiring dedicated neurological rehabilitation.
- Cholinergic drugs and antihypoxic agents are recommended as supportive therapies.
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