Relationship between PPAR-γ gene polymorphisms and ischemic stroke risk: A meta-analysis
Fan Cheng1, Xiao-Min Si1,2, Gong-Li Yang3
1Center of Cardiopulmonary Rehabilitation, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Brain and Behavior
|November 10, 2021
Summary
This meta-analysis found that the PPAR-γ rs1801282 C/G gene polymorphism is associated with an increased risk of ischemic stroke (IS). Further research is needed to confirm these findings on PPAR-γ and IS development.
Area of Science:
- Genetics
- Neurology
- Molecular Biology
Background:
- Emerging research suggests a link between Peroxisome proliferator-activated receptor gamma (PPAR-γ) and the development of ischemic stroke (IS).
- Genetic variations in PPAR-γ may influence an individual's susceptibility to IS.
Purpose of the Study:
- To conduct a meta-analysis evaluating the association between specific PPAR-γ gene polymorphisms (rs1801282 C/G and rs3856806 C/T) and the risk of developing IS.
- To synthesize existing evidence to provide a clearer understanding of the genetic contribution to IS.
Main Methods:
- A systematic literature search was performed across major scientific databases (PubMed, Embase, Web of Science, CNKI, WanFang).
- Meta-analysis techniques were employed to pool odds ratios (ORs) and 95% confidence intervals (CIs) for the selected PPAR-γ polymorphisms.
- Statistical analyses included heterogeneity testing, cumulative and sensitivity analyses, and publication bias assessment.
Main Results:
- Sixteen studies comprising 3786 cases and 5343 controls were included.
- The PPAR-γ rs1801282 C/G polymorphism was significantly associated with an increased risk of IS (GG vs. CC: OR=2.17, 95%CI=1.09-4.35; GG vs. CC+CG: OR=2.15, 95%CI=1.07-4.32).
- No significant association was found between the PPAR-γ rs3856806 C/T polymorphism and IS risk.
Conclusions:
- The PPAR-γ rs1801282 C/G polymorphism likely plays a role in the occurrence of ischemic stroke.
- These findings highlight a potential genetic marker for IS risk, but require validation through additional prospective studies.
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