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Updated: Oct 13, 2025

Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate
Published on: April 24, 2018
Transition Metal-Free, Methoxide-Catalyzed Synthesis of Pyridoindolones
Sun-A Park1, Jong-Un Park1, Ye Lim Kim1
1Department of Chemistry (BK21 Four), Research Institute of Natural Science, Gyeongsang National University, 52828 Jinju, Korea.
Abstract:
A simple transition metal-free strategy for the synthesis of pyrido[1,2-a]indolone derivatives has been devised through sodium methoxide-catalyzed intramolecular cyclization of 2-alkenylated N-pyrimidyl indoles. The reactions involved a Smiles rearrangement/cyclization cascade, which resulted in a new series of N-fused indoles, potentially applicable skeletons in medicinal chemistry. This reaction presents simple eco-friendly reaction conditions, a high atom- and cost-economy, a short reaction time, and a broad range of substrate scope with high reaction efficiency.
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