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Updated: Oct 13, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Left bundle branch pacing in heart failure patients with left bundle branch block: A systematic review and

Yuda Cheng1, Zhanqi Wang1, Yujun Li1

  • 1Department of Cardiology, Affiliated Hospital of Hebei University, YuHua street, Baoding, Hebei, 071000, China.

Pacing and Clinical Electrophysiology : PACE
|November 12, 2021
PubMed

Insights

Left bundle branch pacing (LBBP) shows significant efficacy and safety in heart failure patients with left bundle branch block (LBBB). This novel pacing strategy improves key cardiac metrics and clinical outcomes, offering a promising alternative to traditional CRT.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Management

Background:

  • Cardiac resynchronization therapy (CRT) benefits heart failure patients with left bundle branch block (LBBB).
  • A significant non-response rate exists for CRT, necessitating alternative approaches.
  • Left bundle branch pacing (LBBP) has emerged as a potentially effective CRT strategy.

Purpose of the Study:

  • To evaluate the efficacy and safety of LBBP in heart failure patients diagnosed with LBBB.
  • To compare the outcomes of LBBP with baseline and biventricular pacing (BVP).

Main Methods:

  • A systematic literature search was conducted across PubMed, Cochrane Library, Web of Science, and CNKI.
  • Data on QRS duration, NYHA class, BNP, LVEF, LVEDD, and pacing parameters were extracted.
  • Meta-analysis techniques were employed to summarize findings from 6 included studies.

Main Results:

  • LBBP demonstrated a high success rate (93.2%) and significantly shortened QRS duration.
  • Improvements were observed in echocardiographic parameters (LVEF, LVEDD) and clinical outcomes (NYHA, BNP).
  • LBBP showed superior outcomes compared to BVP in several key metrics, with a low complication rate (2.4%).

Conclusions:

  • LBBP is an effective and safe pacing strategy for heart failure patients with LBBB.
  • Further randomized controlled trials are needed to definitively establish LBBP's superiority over BVP.
Abstract

Keywords:
biventricular pacingcardiac resynchronization therapyheart failureleft bundle branch blockleft bundle branch pacing

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