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    A new dropless protocol using injections for micro-incision vitrectomy surgery (MIVS) showed promising results. While visual acuity improved and endophthalmitis was rare, further research is needed to confirm the safety of this dropless approach.

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    Area of Science:

    • Ophthalmology
    • Surgical Innovation
    • Retinal Surgery

    Background:

    • Micro-incision vitrectomy surgery (MIVS) often requires topical postoperative eye drops.
    • Managing postoperative eye drop regimens can be challenging for patients.

    Purpose of the Study:

    • To evaluate the outcomes of a novel dropless protocol for patients undergoing MIVS.
    • To assess the safety and efficacy of subconjunctival and intravitreal injections as an alternative to topical drops.

    Main Methods:

    • A retrospective, single-center study of 451 MIVS cases.
    • Patients received subconjunctival cefazolin:dexamethasone and posterior sub-Tenon's Kenalog injections postoperatively.
    • Primary outcome was postoperative endophthalmitis; visual acuity and intraocular pressure were also monitored.

    Main Results:

    • One presumed case of endophthalmitis with negative cultures.
    • Mean best-corrected visual acuity improved postoperatively (P = 0.004).
    • Mean intraocular pressure showed a slight increase postoperatively (P < 0.001).

    Conclusions:

    • The novel dropless protocol may offer a convenient alternative for MIVS patients.
    • Further investigation is necessary to establish the long-term safety of this dropless regimen.