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Towards Biomanufacturing of Cell-Derived Matrices.

Weng Wan Chan1, Fang Yu2, Quang Bach Le1

  • 1Biomanufacturing Technology, Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, Singapore 138668, Singapore.

International Journal of Molecular Sciences
|November 13, 2021
PubMed
Summary
This summary is machine-generated.

Cell-derived matrices (CDM) offer a promising animal-free alternative for biomedical applications. Scaling up CDM production is crucial for clinical translation, requiring careful consideration of manufacturing technologies and challenges.

Keywords:
CDMbioinkbiomanufacturingbiomaterialsbioprintingcell-derived matricesdECMdecellularised extracellular matrixextracellular matrixhydrogels

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Cell-derived matrices (CDM) are decellularized extracellular matrices (ECM) from cultured cells, mimicking natural tissue properties.
  • CDM offers tailored composition for applications like stem cell niches, disease modeling, and regenerative medicine, reducing animal use.
  • Current research focuses on CDM extraction and utilization, with limited attention to production scale-up.

Purpose of the Study:

  • To review current cell-derived matrix (CDM) production and characterization methods.
  • To describe existing scale-up technologies for cell culture relevant to CDM manufacturing.
  • To highlight key considerations and challenges in scaling up CDM production for industrial application.

Main Methods:

  • Review of literature on CDM production, characterization, and scale-up technologies.
  • Analysis of cell culture scale-up methods applicable to CDM manufacturing.
  • Discussion of challenges in transitioning laboratory-scale CDM protocols to industrial processes.

Main Results:

  • CDM production methods can be optimized for specific applications.
  • Existing cell culture scale-up technologies provide a foundation for CDM manufacturing.
  • Significant challenges exist in scaling up CDM production, including technological gaps.

Conclusions:

  • Scaling up cell-derived matrix (CDM) production is essential for clinical translation and regulatory approval.
  • Early identification of scale-up challenges and technological gaps is vital for efficient product development.
  • Advancements in scale-up cell culture and ECM extraction technologies are needed to support industrial CDM manufacturing.