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Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
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Angiogenesis in Chronic Inflammatory Skin Disorders.
Hyun Ji Lee1, Yong Jun Hong1, Miri Kim1
1Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, #10, 63-ro, Yeongdeungpo-gu, Seoul 07345, Korea.
International Journal of Molecular Sciences
|November 13, 2021
Summary
New blood vessel growth, known as angiogenesis, is linked to inflammation in skin diseases like psoriasis and rosacea. Targeting this process may offer new treatments for chronic inflammatory skin conditions.
Area of Science:
- Dermatology
- Molecular Biology
- Pathology
Background:
- Angiogenesis, the formation of new blood vessels, is a critical process in various pathological conditions, particularly inflammatory skin diseases.
- Key angiogenic factors include vascular endothelial growth factor (VEGF) and angiopoietins, with Yes-associated protein 1 (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) recently identified as significant contributors.
- Chronic inflammatory skin conditions such as psoriasis, atopic dermatitis, rosacea, chronic urticaria, and hidradenitis suppurativa exhibit strong associations with aberrant angiogenesis.
Purpose of the Study:
- To explore the role of angiogenesis in the pathogenesis of chronic inflammatory skin diseases.
- To identify key molecular factors driving angiogenesis in these conditions.
- To evaluate the therapeutic potential of inhibiting angiogenesis for treating inflammatory skin disorders.
Main Methods:
- Review of existing literature on angiogenesis and inflammatory skin diseases.
- Analysis of molecular pathways and factors involved in angiogenesis.
- Correlation of angiogenic processes with specific disease pathologies.
Main Results:
- Psoriasis pathogenesis involves dysregulated angiogenesis driven by factors like VEGF, angiopoietins, TNF-a, IL-8, and IL-17.
- Atopic dermatitis pathogenesis may involve angiogenesis, with mast cells being a primary source of VEGF.
- Rosacea pathogenesis is characterized by microorganism-induced LL-37 signaling, leading to VEGF and MMP-3 release from mast cells, promoting angiogenesis.
- Increased VEGF expression is observed in chronic urticaria and hidradenitis suppurativa.
Conclusions:
- Angiogenesis is a fundamental process in the development of numerous chronic inflammatory skin diseases.
- VEGF is a crucial mediator of angiogenesis across various inflammatory dermatoses.
- Inhibition of angiogenesis presents a promising therapeutic strategy for managing chronic inflammatory skin disorders.
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