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Updated: Oct 13, 2025

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
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Functionalizing Framework Nucleic-Acid-Based Nanostructures for Biomedical Application.

Tao Zhang1, Taoran Tian1, Yunfeng Lin2,3

  • 1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)
|November 17, 2021
PubMed
Summary

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This summary is machine-generated.

Tetrahedral framework nucleic acids (tFNAs) offer unique biomedical potential due to their ROS scavenging and enhanced cellular uptake. Their programmable structure enables diverse applications in targeted therapies and regenerative medicine.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Molecular Biology

Background:

  • Tetrahedral framework nucleic acids (tFNAs) are DNA nanostructures with diverse applications.
  • One-pot annealing of DNA single strands is a common and efficient method for tFNA synthesis.
  • Previous research has explored various strategies for functionalizing tFNAs.

Purpose of the Study:

  • To review the key merits of tFNAs for biomedical applications.
  • To highlight the potential of tFNAs in treating inflammatory and degenerative diseases.
  • To discuss the development of static and dynamic tFNAs for advanced therapeutic strategies.

Main Methods:

  • Review of existing literature on tFNA fabrication and functionalization.
  • Analysis of tFNA properties, including ROS scavenging, cellular endocytosis, and tissue permeability.
Keywords:
ROS scavengingantibacterial therapyanticancer therapydrug deliverydynamic DNA structuretetrahedral framework nucleic acidstissue engineering

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  • Exploration of structural programmability for static and dynamic tFNA development.

    • Main Results:

    • tFNAs exhibit natural reactive oxygen species (ROS) scavenging abilities.
    • tFNAs demonstrate enhanced cellular endocytosis and tissue permeability due to their size and geometry.
    • Structural programmability allows for the creation of static and dynamic tFNAs for targeted applications.

    Conclusions:

    • tFNAs show significant promise for biomedical applications, including targeted therapies, tissue regeneration, and antitumor strategies.
    • Further research into the functionalization of tFNA-based nanostructures is warranted.
    • tFNAs represent a versatile platform for developing advanced nanomedicines.