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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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Related Experiment Video

Updated: Oct 13, 2025

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InsectBase 2.0: a comprehensive gene resource for insects.

Yang Mei1, Dong Jing1, Shenyang Tang1

  • 1State Key Laboratory of Rice Biology & Ministry of Agricultural and Rural Affairs Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China.

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Summary
This summary is machine-generated.

InsectBase 2.0 is a comprehensive database managing over 815 insect genomes and 16 million genes. This valuable resource aids entomologists and researchers in insect genomics and evolutionary studies.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Entomology

Background:

  • Insects significantly impact human life and agriculture.
  • Vast amounts of insect genomic and gene data are increasingly available.
  • A centralized database is crucial for managing and analyzing this data.

Purpose of the Study:

  • To present InsectBase 2.0, an updated and comprehensive database for insect genomic resources.
  • To provide integrated data including genomes, transcriptomes, genes, and pathways.
  • To offer web services for data exploration and visualization.

Main Methods:

  • Compiled data from 815 insect genomes and 25,805 transcriptomes.
  • Annotated over 1.4 million genes, identifying gene families, horizontally transferred genes, and KEGG pathways.
  • Integrated web services like BLAST and JBrowse2 for user-friendly access.

Main Results:

  • InsectBase 2.0 hosts data for 815 insect genomes and >16 million genes.
  • Includes extensive annotations for coding sequences, UTRs, miRNAs, and lncRNAs.
  • Provides access to 164 gene families, 215,986 horizontally transferred genes, and 419 KEGG pathways.

Conclusions:

  • InsectBase 2.0 is a powerful, updated platform for insect genomic research.
  • Facilitates data management, sharing, and mining for entomologists and comparative genomics researchers.
  • Enhances the study of insect evolution and comparative genomics through integrated data and tools.