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Related Concept Videos

Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

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Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
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Cancer Survival Analysis01:21

Cancer Survival Analysis

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Related Experiment Video

Updated: Oct 13, 2025

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
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Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation

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[Restatment. Anal Cancer].

Véronique Vendrely1

  • 1Service d'oncologieradiothérapie, hôpital Haut-Lévêque, CHU de Bordeaux, INSERM U1035, Université de Bordeaux, France.

La Revue Du Praticien
|November 18, 2021
PubMed
Summary

Anal cancer incidence is rising, often linked to HPV. Current standard treatment is chemoradiotherapy (CRT), with ongoing research into personalized medicine and immunotherapy for better outcomes.

Area of Science:

  • Oncology
  • Epidemiology

Background:

  • Anal cancer, though rare, shows increasing incidence linked to Human Papillomavirus (HPV) prevalence.
  • Squamous cell carcinoma is the predominant histological type, with frequent pelvic lymph node involvement but infrequent metastasis.
  • Current standard treatment involves chemoradiotherapy (CRT), achieving good loco-regional control.

Purpose of the Study:

  • To review the current landscape of anal cancer treatment and management.
  • To highlight recent advancements and future directions in anal cancer therapy.
  • To discuss the role of HPV in anal cancer etiology and prevention.

Main Methods:

  • Review of current literature on anal cancer incidence, pathology, and treatment.
  • Analysis of the efficacy of chemoradiotherapy (CRT) and salvage surgery.
Keywords:
Anus Neoplasms

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  • Discussion of emerging therapeutic strategies, including personalized medicine and immunotherapy.

    • Main Results:

    • Chemoradiotherapy (CRT) is the established standard of care for anal cancer.
    • Technological advances in radiotherapy and radiology have improved outcomes.
    • Chemotherapy regimens have remained largely unchanged for decades.

    Conclusions:

    • Personalized treatment strategies considering tumor staging and patient characteristics are under investigation.
    • Immunotherapy and HPV vaccination represent promising future directions for anal cancer management.
    • Further research is needed to optimize chemotherapy and explore novel therapeutic approaches.