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Microscale electrokinetic-based analysis of intact cells and viruses
Alaleh Vaghef-Koodehi1, Blanca H Lapizco-Encinas1
1Microscale Bioseparations Laboratory and Biomedical Engineering Department, Rochester Institute of Technology, Rochester, NY, USA.
Electrophoresis
|November 19, 2021
Summary
Miniaturized electrokinetic techniques offer rapid and integrated analysis of microorganisms. This review covers electromigration, electrode-based, and insulator-based methods for cell and virus assessment.
Area of Science:
- Biophysical techniques
- Microscale engineering
- Analytical chemistry
Background:
- Miniaturized electrokinetic methods provide robust platforms for analyzing intact microorganisms.
- These techniques offer advantages over traditional bench-scale methods, including shorter response times and enhanced integration.
Purpose of the Study:
- To review the state-of-the-art in microscale electrokinetic techniques for analyzing intact cells and viruses.
- To provide an overview of electromigration, electrode-based, and insulator-based electrokinetic methodologies.
Main Methods:
- Discussion of the fundamentals of three electrokinetic methodologies: electromigration (motion-based), electrode-based, and insulator-based electrokinetics.
- Examination of relevant examples from recent scientific reports.
Main Results:
- Electrokinetic techniques are effective for the analysis and assessment of intact microorganisms.
- Recent advancements showcase the capabilities of microscale electrokinetic techniques in cell and virus analysis.
Conclusions:
- Microscale electrokinetic techniques represent a significant advancement in microorganism analysis.
- Future directions and potential applications of these methods are discussed.
