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Bilateral Occlusive Vasculitis Associated with Retinitis Pigmentosa - A Case Report
Eliza Anthony1, Prabu Baskaran2, Archana Rajamani2
1Uvea Services, Aravind Eye Hospital, Chennai, India.
Ocular Immunology and Inflammation
|November 19, 2021
Summary
Retinitis pigmentosa (RP) can rarely present with intraocular tuberculosis (IOTB). Combined oral steroids and antitubercular therapy (ATT), with intravitreal ranibizumab for central retinal vein occlusion, improved vision in a case report.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Genetics
Background:
- Retinitis pigmentosa (RP) is a group of inherited retinal diseases.
- RP is characterized by progressive vision loss, primarily night blindness and peripheral vision loss.
- Ocular inflammatory conditions can sometimes be associated with RP.
Observation:
- A 34-year-old male with a history of night blindness presented with acute blurred vision.
- Ophthalmoscopy revealed bilateral RP with central retinal vein occlusion (CRVO) in the right eye and occlusive vasculitis with macular edema in the left eye.
- Clinical features, Mantoux test, and chest CT suggested presumed intraocular tuberculosis (IOTB).
Findings:
- The patient received oral steroids, antitubercular therapy (ATT), and six intravitreal ranibizumab injections in the right eye.
- At 7-month follow-up, best corrected visual acuity improved from OD 20/63 and OS 20/200 to OD 20/40 and OS 20/80.
- This case highlights a rare association between RP and presumed IOTB.
Implications:
- RP may rarely be associated with intraocular tuberculosis.
- A combination of oral steroids and ATT is a potential treatment strategy.
- Intravitreal ranibizumab may be beneficial for managing inflammatory central retinal vein occlusion in such cases.
