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Various bifurcations in the development of stem cells
Lianyu Chen1, Ibrahim Ismael Hamarash2,3, Sajad Jafari4,5
1School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou, 213001 China.
The European Physical Journal. Special Topics
|November 22, 2021
Summary
Stem cell development involves chaotic gene expression transitioning to ordered states, leading to cell differentiation. This study models these changes, identifying critical bifurcation points using critical slowing down indicators.
Area of Science:
- Developmental Biology
- Systems Biology
- Computational Biology
Background:
- Cell development from stem cells to differentiated cells is crucial for organism formation.
- Furusawa and Kaneko's hypothesis posits chaotic gene expression in stem cells, which becomes ordered during differentiation, causing pluripotency loss.
Purpose of the Study:
- To model and analyze stem cell development and differentiation.
- To investigate the chaotic to ordered gene expression dynamics during cell development.
- To identify and predict bifurcation points in cell development.
Main Methods:
- Utilized a computational model based on Furusawa and Kaneko's hypothesis.
- Analyzed gene expression dynamics from chaotic to ordered states.
- Employed critical slowing down indicators to detect variations and predict bifurcation points.
Main Results:
- Observed various patterns and identified critical bifurcation points during simulated cell development.
- Demonstrated that chaotic gene expression in stem cells transitions to ordered states.
- Critical slowing down indicators showed predictable trends approaching and receding from bifurcation points.
Conclusions:
- The study successfully models the transition of gene expression from chaotic to ordered states during stem cell differentiation.
- Bifurcation points in cell development can be identified and predicted using critical slowing down indicators.
- Understanding these transitions is vital for preventing developmental disruptions.
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