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Updated: Oct 12, 2025
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Photoinduced Radical Cascade Cyclization: A Metal-Free Approach to Access Difluoroalkylated Dioxodibenzothiazepines
Qian Xiao1,2, Maojian Lu1, Yinglan Deng1
1Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University and Chemistry and Chemical Engineering Guangdong Laboratory, Shantou, Guangdong 515063, P. R. China.
Abstract:
A simple and mild photoredox catalytic approach to access difluoroalkylated dioxodibenzothiazepines in high regioselectivity via radical cascade cyclization has been described herein. In contrast to previous methods, this strategy does not involve the use of transition-metal catalysts and avoids the potential disadvantages of inevitable toxicity and the tedious removal process of metal catalysts. The commercially available and inexpensive CF2 precursors, wide substrate scope, and mild reaction conditions demonstrate the practicability of this approach.
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