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Anti-TIF-1α/γ Antibody-Positive Dermatomyositis Associated With Metastatic Prostatic Adenocarcinoma
Corinna E Psomadakis1, Samuel Z Maron2, Melissa J Ng3
1Department of Medicine, Sinai West and Morningside, New York, NY.
Journal of Clinical Neuromuscular Disease
|November 22, 2021
Summary
Dermatomyositis, an autoimmune disease, can present with severe swallowing and breathing issues. This case highlights a rare association between dermatomyositis and metastatic prostate cancer, identified via anti-TIF-1 antibodies.
Area of Science:
- Autoimmune diseases
- Neuromuscular disorders
- Oncology
Background:
- Dermatomyositis (DM) is an autoimmune myopathy causing muscle weakness and skin issues.
- DM in adults is linked to a higher risk of developing cancer.
Observation:
- A patient presented with severe oropharyngeal dysphagia and respiratory muscle weakness.
- This patient was diagnosed with metastatic prostate cancer.
Findings:
- Prostate cancer is rarely associated with dermatomyositis.
- The patient tested positive for anti-TIF-1 antibodies, associated with malignancy-related DM.
- Anti-TIF-1 antibodies correlate with dysphagia and severe skin manifestations in DM.
Implications:
- This case underscores the importance of investigating malignancy in DM patients with severe dysphagia.
- The anti-TIF-1 antibody marker may aid in identifying DM patients with underlying cancers.
- Early detection of associated cancers can potentially improve patient outcomes.
