Related Experiment Video
Updated: Oct 12, 2025

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography
Published on: November 30, 2022
DDA-Net: Unsupervised cross-modality medical image segmentation via dual domain adaptation
Xuesheng Bian1, Xiongbiao Luo2, Cheng Wang1
1Fujian Key Laboratory of Sensing and Computing for Smart Cities, Department of Computer Science, School of Informatics, Xiamen University, Xiamen 361005, China; National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen 361005, China.
Background And Objective:
Deep convolutional networks are powerful tools for single-modality medical image segmentation, whereas generally require semantic labelling or annotation that is laborious and time-consuming. However, domain shift among various modalities critically deteriorates the performance of deep convolutional networks if only trained by single-modality labelling data.
Methods:
In this paper, we propose an end-to-end unsupervised cross-modality segmentation network, DDA-Net, for accurate medical image segmentation without semantic annotation or labelling on the target domain. To close the domain gap, different images with domain shift are mapped into a shared domain-invariant representation space. In addition, spatial position information, which benefits the spatial structure consistency for semantic information, is preserved by an introduced cross-modality auto-encoder.
Results:
We validated the proposed DDA-Net method on cross-modality medical image datasets of brain images and heart images. The experimental results show that DDA-Net effectively alleviates domain shift and suppresses model degradation.
Conclusions:
The proposed DDA-Net successfully closes the domain gap between different modalities of medical image, and achieves state-of-the-art performance in cross-modality medical image segmentation. It also can be generalized for other semi-supervised or unsupervised segmentation tasks in some other field.

