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The Extracellular Matrix

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Updated: Oct 12, 2025

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Published on: December 4, 2017

Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering.

Astha Khanna¹, Maedeh Zamani^2,3, Ngan F Huang^2,3,4,5

¹Graver Technologies, Newark, NJ 07105, USA.

Journal of Cardiovascular Development and Disease

|November 25, 2021

Summary

This summary is machine-generated.

This review explores extracellular matrix (ECM)-based biomaterials for cardiovascular tissue engineering. It highlights advancements in designing scaffolds that mimic natural tissue properties for regenerative medicine applications.

Keywords:

extracellular matrix (ECM)regenerative medicine tissue engineering

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Related Experiment Videos

Last Updated: Oct 12, 2025

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Published on: December 4, 2017

Author Spotlight: Studying Cardiac Cell-Matrix Interactions In Vitro

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Published on: March 22, 2024

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

Area of Science:

Biomaterials Science
Regenerative Medicine
Cardiovascular Engineering

Background:

Tissue engineering aims to repair damaged cardiovascular tissues using advanced biomaterials.
The extracellular matrix (ECM) provides essential biochemical and mechanical cues for cellular function.
Biomaterial scaffolds are being developed to better replicate physiological ECM properties.

Purpose of the Study:

To review research models for designing ECM-based biomaterials in cardiovascular regenerative medicine.
To highlight advancements in ECM component incorporation, scaffold engineering, and vascular applications.
To discuss challenges and future directions for ECM-based biomaterials in tissue engineering.

Main Methods:

Review of in vitro, pre-clinical, and clinical research models.
Analysis of ECM component incorporation into biomaterial scaffolds.
Examination of biofabrication and spatial patterning techniques for complex structures.

Main Results:

ECM-based scaffolds show promise in mimicking physiological properties and guiding cellular behavior.
Advancements include improved scaffold complexity and regulation of vascular differentiation.
Successful translation of ECM-based scaffolds for vascular graft applications is demonstrated.

Conclusions:

ECM-based biomaterials are crucial for cardiovascular tissue engineering and regenerative medicine.
Continued research is needed to overcome challenges in scaffold design and clinical translation.
Future directions focus on next-generation biomaterials for enhanced cardiovascular repair.