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EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Related Experiment Video

Updated: Jan 14, 2026

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices

Published on: June 16, 2020

Human iPSC-Based in Vitro Cardiovascular Tissue Models for Drug Screening Applications.

Shivesh Anand^1,2,3, Gaoxian Chen^1,2,3, Astha Khanna⁴

¹Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, 94305, USA.

Current Cardiology Reports

|October 23, 2025

Summary

This summary is machine-generated.

Human induced pluripotent stem cells (hiPSCs) can differentiate into cardiovascular lineages for advanced in vitro drug testing. These hiPSC-derived models improve the accuracy of drug screening and target identification.

Keywords:

Cardiovascular Drug screening Induced pluripotent stem cell Organ-on-a-chip Tissue engineering

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Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

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Last Updated: Jan 14, 2026

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices

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Generation, High-Throughput Screening, and Biobanking of Human-Induced Pluripotent Stem Cell-Derived Cardiac Spheroids

Generation, High-Throughput Screening, and Biobanking of Human-Induced Pluripotent Stem Cell-Derived Cardiac Spheroids

Published on: March 10, 2023

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

Area of Science:

Stem Cell Biology
Cardiovascular Research
Drug Discovery

Background:

Human induced pluripotent stem cells (hiPSCs) offer a promising source for generating various cell types.
Cardiovascular lineages derived from hiPSCs are crucial for regenerative medicine and disease modeling.

Purpose of the Study:

To review human induced pluripotent stem cell (hiPSC)-derived cardiovascular lineages.
To describe their impact on in vitro drug testing.

Main Methods:

Utilizing tissue engineering, 3D bioprinting, and organ-on-a-chip platforms.
Generating cardiovascular tissue mimetics from hiPSC derivatives.
Employing established approaches for reproducible generation of hiPSC-derived cardiovascular lineages.

Main Results:

hiPSCs can be differentiated into cardiovascular lineages with potential for unlimited proliferation.
hiPSC derivatives form cardiovascular tissue mimetics that enhance drug screening.
Autologous hiPSC-derived cells offer greater therapeutic relevance in drug screening.

Conclusions:

hiPSC-derived cardiovascular lineages are advancing drug screening applications.
3D constructs mimic cardiac tissue physiology, improving drug target identification.
These models enhance the accuracy and relevance of in vitro drug testing.