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MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges
Published on: December 17, 2014
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Multi-vendor and multisite evaluation of cerebrovascular reactivity mapping using hypercapnia challenge
Peiying Liu1, Dengrong Jiang1, Marilyn Albert2
1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Neuroimage
|November 26, 2021
Summary
Cerebrovascular reactivity (CVR) measured with CO2 inhalation MRI shows good reliability across different scanners and raters. This supports its use as a brain imaging biomarker in multi-site studies.
Area of Science:
- Neuroimaging
- Vascular Biology
- Biomarker Development
Background:
- Cerebrovascular reactivity (CVR) is crucial for assessing brain vascular health.
- BOLD MRI with hypercapnia challenge shows promise for CVR quantification.
- Reliability across sites and scanners is essential for CVR as a biomarker.
Purpose of the Study:
- To evaluate the inter-rater, inter-scanner, and test-retest reliability of CO2-CVR quantification.
- To assess the suitability of CO2-CVR for multi-site and longitudinal studies.
Main Methods:
- Inter-rater reliability assessed using a cloud-based pipeline across 5 sites.
- Inter-scanner reproducibility evaluated in 10 subjects across 2 different vendor scanners.
- Test-retest repeatability assessed in 20 subjects across 4 sites with <2-week interval.
Main Results:
- Inter-rater CoV for whole-brain CVR was 0.08 ± 0.08%, with ICC > 0.9959.
- Inter-scanner CoV for whole-brain CVR was 6.90 ± 5.08%, with ICC 0.8498.
- Test-retest CoV for whole-brain CVR was 18.29 ± 17.12%, with ICC 0.6480–0.7785.
Conclusions:
- CO2-CVR quantification demonstrates good inter-rater and inter-scanner reliability.
- Test-retest repeatability is acceptable, supporting its use in longitudinal studies.
- CO2-CVR possesses suitable properties for use as a cerebrovascular imaging biomarker.
