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Updated: Oct 12, 2025

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Fluorescent Laparoscopic Central Hepatectomy for Liver Cancer Using Indocyanine Green Negative Staining
Published on: March 17, 2023
926
Fluorescence Image-Guided Navigation Surgery Using Indocyanine Green for Hepatoblastoma
Eiso Hiyama1,2
1Department of Pediatric Surgery, Hiroshima University Hospital, Hiroshima 734-8551, Japan.
Children (Basel, Switzerland)
|November 27, 2021
Summary
Indocyanine green (ICG) fluorescence navigation surgery aids hepatoblastoma (HB) resection by detecting residual and metastatic tumors. This technique may improve treatment outcomes for HB patients.
Area of Science:
- Surgical Oncology
- Medical Imaging
Background:
- Hepatoblastoma (HB) treatment relies on complete tumor resection.
- Indocyanine green (ICG) dye uptake by HB cells, without biliary excretion, enables fluorescent visualization.
- ICG fluorescence offers potential for detecting microscopic residual disease and metastases.
Purpose of the Study:
- To review the technique and recent advances in ICG navigation for hepatoblastoma surgery.
Main Methods:
- Utilizing indocyanine green (ICG) dye for intraoperative fluorescent visualization.
- Applying ICG fluorescence to identify primary and metastatic hepatoblastoma lesions.
- Reviewing current literature on ICG navigation in HB surgery.
Main Results:
- ICG remains within HB cells, allowing for fluorescent navigation during surgery.
- Fluorescence can detect microscopic residual lesions and lung micro-metastases.
- ICG navigation surgery shows promise for improving patient outcomes in HB.
Conclusions:
- ICG navigation surgery is a valuable tool for complete resection in hepatoblastoma.
- This technique enhances the detection of residual and metastatic disease.
- ICG fluorescence-guided surgery may lead to better prognoses for HB patients.

