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Synthetic Biology

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Biosynthesis in bacteria is a fundamental anabolic process that generates essential macromolecules, including proteins, nucleic acids, lipids, and polysaccharides. These macromolecules are critical for cellular growth, replication, and function. The process is tightly regulated and energetically linked to catabolic pathways to ensure optimal resource utilization.Biosynthetic pathways begin with precursor metabolites such as pyruvate, acetyl-CoA, and glucose-6-phosphate derived from glycolysis,...

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A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

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Published on: October 6, 2019

Build-a-Cell: Engineering a Synthetic Cell Community.

Caroline Frischmon¹, Carlise Sorenson², Michael Winikoff¹

¹Science Communication Lab., BioTechnology Institute, University of Minnesota, Minneapolis, MN 55108, USA.

Life (Basel, Switzerland)

|November 27, 2021

Summary

This summary is machine-generated.

The Build-a-Cell initiative is a global research network focused on creating synthetic living cells. This ambitious project aims to advance biotechnology by integrating individual cellular functions into novel, artificial cells.

Keywords:

artificial life bioengineering cell-free liposomes synthetic biology synthetic cells

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Last Updated: Oct 12, 2025

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Area of Science:

Synthetic Biology
Biotechnology
Cellular Engineering

Background:

Current research can replicate individual cellular functions.
Integrating these functions into a single, artificial cell presents a significant scientific challenge.
A large-scale, collaborative approach is necessary to overcome these integration hurdles.

Purpose of the Study:

To review the history, function, and goals of the Build-a-Cell global research network.
To highlight the potential of synthetic cells to revolutionize the biotechnology industry.
To discuss the collaborative model required for advancing synthetic cell development.

Main Methods:

The Build-a-Cell network employs an open, collective research structure.
It facilitates large-scale collaboration among scientists and engineers.
The initiative integrates research on individual cellular functions towards a unified synthetic cell.

Main Results:

The review details the foundational history and operational framework of Build-a-Cell.
It outlines the network's progress towards the decade-long goal of developing synthetic living cells.
The potential impact of synthetic cells on biological understanding and the biotech industry is discussed.

Conclusions:

Build-a-Cell's collaborative model is crucial for achieving the complex goal of synthetic cell creation.
Synthetic cells promise to significantly advance the understanding of fundamental biology.
The initiative also addresses critical policy and biosecurity considerations for emerging biotechnologies.