Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Synthetic Biology

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Purification of post-transcriptionally modified tRNAs for enhanced cell-free translation systems.

Nucleic acids research·2026

Same author

CyanoConstruct: simple platform for cyanobacterial expression construct assembly and translational tuning.

BMC biotechnology·2026

Same author

One-pot cloning and protein expression platform for genetic engineering.

bioRxiv : the preprint server for biology·2025

Same author

High Yield, Low Magnesium Flexizyme Reactions in a Water-Ice Eutectic Phase.

Biochemistry·2025

Same author

Purification of post-transcriptionally modified tRNAs for enhanced cell-free translation systems.

bioRxiv : the preprint server for biology·2025

Same author

A Triple-pose Complex Between an Extended WIP Motif and a C-terminal SH3 Domain Modulates Cortactin Activity.

Journal of molecular biology·2025

Same journal

Repeated insertions at positions 261-280 in KPC-2 highlight a ceftazidime-avibactam resistance hotspot.

iScience·2026

Same journal

ROS inhibits microtubule dynamics and cell growth heterogeneity during Arabidopsis sepal morphogenesis.

iScience·2026

Same journal

Type 1 diabetes alters early macrophage-<i>Mycobacterium tuberculosis</i> transcriptional coordination during infection.

iScience·2026

Same journal

Association of estimated pulse wave velocity with non-alcoholic fatty liver disease in multiple cohorts.

iScience·2026

Same journal

Effect of rolling surface texture on bearing friction pairs lubrication.

iScience·2026

Same journal

Whole blood exchange-lymphoplasmapheresis combined transfusion as an immunotherapy in systemic lupus erythematosus.

iScience·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 24, 2026

Preparing Protein Producing Synthetic Cells using Cell Free Bacterial Extracts, Liposomes and Emulsion Transfer

Preparing Protein Producing Synthetic Cells using Cell Free Bacterial Extracts, Liposomes and Emulsion Transfer

Published on: April 27, 2020

Synthetic cells by the numbers.

Chana G Sokolik¹, Maya Bar-Dolev¹, Ron Milo²

¹Faculty of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa 3200003, Israel.

|December 1, 2025

Summary

This summary is machine-generated.

Synthetic cell engineering aims to build living cells from non-living parts. This study quantifies synthetic cell properties to guide future designs and identify remaining challenges in creating autonomous cells.

Keywords:

experimental models in systems biology mathematical biosciences synthetic biology

More Related Videos

Author Spotlight: Optimizing CFPS Systems for Synthetic Cell Construction

Author Spotlight: Optimizing CFPS Systems for Synthetic Cell Construction

Published on: April 19, 2024

Assembly and Quantification of Co-Cultures Combining Heterotrophic Yeast with Phototrophic Sugar-Secreting Cyanobacteria

Assembly and Quantification of Co-Cultures Combining Heterotrophic Yeast with Phototrophic Sugar-Secreting Cyanobacteria

Published on: December 27, 2024

Related Experiment Videos

Last Updated: Apr 24, 2026

Preparing Protein Producing Synthetic Cells using Cell Free Bacterial Extracts, Liposomes and Emulsion Transfer

Preparing Protein Producing Synthetic Cells using Cell Free Bacterial Extracts, Liposomes and Emulsion Transfer

Published on: April 27, 2020

Author Spotlight: Optimizing CFPS Systems for Synthetic Cell Construction

Author Spotlight: Optimizing CFPS Systems for Synthetic Cell Construction

Published on: April 19, 2024

Assembly and Quantification of Co-Cultures Combining Heterotrophic Yeast with Phototrophic Sugar-Secreting Cyanobacteria

Assembly and Quantification of Co-Cultures Combining Heterotrophic Yeast with Phototrophic Sugar-Secreting Cyanobacteria

Published on: December 27, 2024

Area of Science:

Synthetic biology
Biochemistry
Cellular engineering

Background:

The field of synthetic cell engineering seeks to construct artificial cells from non-living molecular components.
Current research focuses on reconstituting and integrating cellular processes into increasingly complex synthetic systems.

Purpose of the Study:

To provide a quantitative overview of synthetic cell properties using a "by the numbers" approach.
To clarify the capabilities and limitations of current synthetic cell systems.
To guide future design efforts in synthetic cell engineering.

Main Methods:

Compilation and contextualization of numerical estimates from existing literature.
Focus on liposome-based synthetic cell systems.
Quantitative analysis of structural, biochemical, and functional characteristics.

Main Results:

A quantitative assessment of current synthetic cell performance.
Identification of key challenges in achieving autonomous synthetic cells.
Insight into the limitations of current liposome-based systems.

Conclusions:

A quantitative approach is essential for understanding and advancing synthetic cell engineering.
Significant challenges remain in building fully autonomous synthetic cells.
Further research is needed to overcome current performance limitations.