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Related Experiment Video

Updated: Oct 11, 2025

Intravitreal Injections in the Ovine Eye

Intravitreal Injections in the Ovine Eye

Published on: July 5, 2022

Intravitreal Methotrexate.

Fatemeh Abdi¹, S Saeed Mohammadi², Khalil Ghasemi Falavarjani^1,3

¹Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Journal of Ophthalmic & Vision Research

|November 29, 2021

Summary

This summary is machine-generated.

Intravitreal methotrexate (MTX) effectively treats certain eye diseases, particularly intraocular lymphoma and uveitis. Further research is needed to confirm its role in other conditions like diabetic retinopathy and macular degeneration.

Keywords:

Intraocular Tumor Intravitreal Injection Methotrexate Proliferative Vitreretinopathy Uveitis Inflammation

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Last Updated: Oct 11, 2025

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Area of Science:

Ophthalmology
Pharmacology

Background:

Intravitreal methotrexate (MTX) is an established treatment for multiple intraocular diseases.
Its efficacy and safety profile necessitate a comprehensive review for broader clinical application.

Purpose of the Study:

To review the intravitreal applications of methotrexate in managing various ocular conditions.
To discuss the administration, indications, and adverse effects of intravitreal MTX.

Main Methods:

A comprehensive literature review was conducted on intravitreal methotrexate administration.
Studies focusing on intraocular tumors, proliferative vitreoretinopathy, diabetic retinopathy, age-related macular degeneration, and uveitis were analyzed.

Main Results:

Intravitreal MTX is most commonly indicated for intraocular lymphoma and uveitis.
Its use in conditions like proliferative vitreoretinopathy, diabetic retinopathy, and age-related macular degeneration requires further investigation.

Conclusions:

Intravitreal methotrexate is a valuable therapeutic option for specific intraocular diseases.
Additional research is essential to fully establish the role of intravitreal MTX in managing a wider range of ocular pathologies.