[Microbe-gut-brain axis and neurological disorders: a review]

Area of Science:

• Neuroscience
• Microbiology
• Gastroenterology

Background:

• Intestinal microbes play a role in neurological health.
• The gut-brain axis is a bidirectional communication system.
• Neurological disorders are increasingly linked to gut health.

Purpose of the Study:

• To review recent advances in the microbe-gut-brain axis.
• To explore the therapeutic potential of targeting the gut microbiome for neurological conditions.
• To provide insights for treating neurodegenerative diseases.

Main Methods:

• Literature review of current research on the gut-brain axis.
• Analysis of studies investigating microbial metabolites and neurological function.
• Examination of neural and immune pathways involved in gut-brain communication.

Main Results:

• Intestinal microbes exert an adjuvant therapeutic effect on neurological disorders.
• The gut-brain axis influences brain function and behavior via neural, immune, and metabolic pathways.
• Specific microbial metabolites are key mediators in this axis.

Conclusions:

• The microbe-gut-brain axis is a significant factor in neurological disorders.
• Targeting the gut microbiome presents novel therapeutic avenues for neurodegenerative diseases.
• Further research into this axis can lead to innovative treatments.