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Updated: Oct 11, 2025

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
Published on: March 26, 2020
The Opto-Respiratory Compromise: Balancing Oxygen Supply and Light Transmittance in the Retina
Christian Damsgaard1,2, Michael W Country3
1Aarhus Institute of Advanced Studies, Aarhus University, Aarhus, Denmark.
Abstract:
The light-absorbing retina has an exceptionally high oxygen demand, which imposes two conflicting needs: high rates of blood perfusion and an unobstructed light path devoid of blood vessels. This review discusses mechanisms and physiological trade-offs underlying retinal oxygen supply in vertebrates and examines how these physiological systems supported the evolution of vision.
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