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Medications and Micronutrients: Identifying Clinically Relevant Interactions and Addressing Nutritional Needs.
Jeffery David Prescott1, Victoria Jayne Drake2, Jan Frederik Stevens2
1Intellisphere, LLC, Cranbury, NJ, USA.
Summary
Drug-nutrient interactions are common, especially with long-term medication use. Pharmacists play a key role in managing these interactions to ensure medication and supplement effectiveness.
Area of Science:
- Pharmacology
- Nutritional Science
- Clinical Pharmacy
Background:
- Prescription drug use is increasing, with over half of US adults using dietary supplements monthly.
- Drug-nutrient interactions are a growing concern for patient counseling.
- Understanding these interactions is crucial for pharmacists.
Purpose of the Study:
- To review the literature and identify common and clinically relevant drug-nutrient interactions.
- To inform pharmacists about potential interactions they may encounter in practice.
Main Methods:
- A MEDLINE search of English-language publications (1970-March 2017) was conducted.
- Search terms included drugs, medications, micronutrients, and interactions.
- Relevant studies, case reports, and reviews were selected.
Main Results:
- Drug-nutrient interactions can lead to micronutrient insufficiencies or deficiencies, particularly with long-term therapy (e.g., proton-pump inhibitors, H2 receptor antagonists).
- Chronic diseases like diabetes can also predispose patients to micronutrient insufficiencies.
- Supplementation may be advisable in certain cases.
Conclusions:
- Drug-nutrient interactions can often be managed with dosing strategies to maintain efficacy of both drugs and supplements.
- Discontinuation or close monitoring of supplements may be necessary in rare instances.
- Pharmacists are vital in identifying and discussing these interactions with patients and healthcare teams.
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