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Prolonged sitting time links to subclinical atherosclerosis
Su Shen Lim1,2, Chin-Chou Huang1,3,2, Pai-Feng Hsu1,3,2,4
1Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Journal of the Chinese Medical Association : JCMA
|December 3, 2021
Summary
Daily prolonged sitting is linked to more severe coronary atherosclerosis and vulnerable plaque formation. This sedentary behavior increases the risk of subclinical atherosclerosis, even in the general population.
Area of Science:
- Cardiology
- Preventive Medicine
- Public Health
Background:
- Subclinical atherosclerosis is a precursor to cardiovascular disease.
- Daily sitting time is a prevalent lifestyle factor with potential health implications.
Purpose of the Study:
- To investigate the association between daily sitting time and subclinical atherosclerosis.
- To analyze the relationship between sedentary behavior and coronary plaque characteristics.
Main Methods:
- Coronary computed tomography angiography (CCTA) was used in 203 subjects.
- Sitting time was categorized into short (<5 hours/day), moderate (5-9 hours/day), and long (≥10 hours/day).
- Coronary calcium score, plaque characteristics, segment involvement score (SIS), and segment stenosis score (SSS) were analyzed.
Main Results:
- Longer sitting time correlated with higher SIS and SSS, indicating increased coronary atherosclerosis severity.
- Subjects with longer sitting times showed a higher prevalence of mixed plaque.
- Increased sitting time was independently associated with the presence of mixed plaque, a marker of vulnerable plaque.
Conclusions:
- Prolonged daily sitting time is associated with more severe subclinical atherosclerosis.
- Sedentary behavior is linked to the presence of high-risk vulnerable plaque.
- Reducing sitting time may be crucial for preventing cardiovascular disease progression.
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