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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
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A Comprehensive Insight on Self Emulsifying Drug Delivery Systems.
1Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.
Recent Advances in Drug Delivery and Formulation
|December 8, 2021
Summary
Self-emulsifying drug delivery systems (SEDDS) improve oral drug delivery for lipophilic drugs by enhancing solubility and dissolution. These systems offer advantages like bypassing first-pass metabolism and reducing variability.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Oral drug delivery is preferred but challenging for lipophilic drugs due to poor aqueous solubility.
- Self-emulsifying drug delivery systems (SEDDS) offer a solution by forming micron or nano-sized globules in the GI tract.
Purpose of the Study:
- To review the mechanisms, benefits, drawbacks, and influencing factors of SEDDS.
- To explore excipient effects, bioavailability enhancement strategies, and evaluation methods for SEDDS.
- To present recent patents related to SEDDS.
Main Methods:
- Incorporation of hydrophobic drugs within oil globules stabilized by surfactant monolayers.
- Utilizing ternary phase diagrams to determine optimal excipient ratios.
- Review of existing literature and patent landscape for SEDDS.
Main Results:
- SEDDS improve the dissolution rate of hydrophobic drugs by reducing interfacial tension.
- Globule size is dependent on the type and ratio of excipients used.
- SEDDS demonstrate the potential to enhance oral bioavailability and solubility of lipophilic compounds.
Conclusions:
- SEDDS offer advantages such as bypassing first-pass metabolism through lymphatic absorption.
- Simplified manufacturing processes and reduced variability (inter/intra-subject, food effects) are key benefits.
- SEDDS represent a promising approach for improving oral delivery of challenging drug compounds.
Keywords:
Bioavailabilitylymphatic transportmechanismpermeation studypoorly aqueous soluble drugsselfemulsifying drug delivery systemsMore Related Videos
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