Near-Infrared Light Triggered H₂ Generation for Enhanced Photothermal/Photodynamic Therapy against Hypoxic Tumor

The principle of photochemical transformation has shown significant inspiration on phototherapy of solid tumors. However, both photodynamic therapy (PDT) and photothermal therapy (PTT) can induce stress response of tumor cells, which draw the attention in recent. Herein, an asymmetric and lollipop like nanostructure consisting of gold nanorod/titanium dioxide (l-TiO₂ -GNR) is developed by controlling single head growth of titanium dioxide (TiO₂ ) on gold nanorods (GNR). Through the reasonable utilization of hot electrons of GNR by 808 nm light irradiation, l-TiO₂ -GNR perform type I-PDT, mild PTT (48 °C), and H₂ therapy which is efficient for hypoxic tumors. In particular, H₂ can downregulate both triphosadenine and heat shock protein which are found to be main source of tumor stress response. l-TiO₂ -GNR opens a new window for treatment of hypoxic tumor by the perfect synergy of type I-PDT, mild PTT, and H₂ therapy.