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Artificial intelligence, molecular subtyping, biomarkers, and precision oncology

John Paul Shen1

  • 1Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, U.S.A.

Emerging Topics in Life Sciences
|December 9, 2021
PubMed

Insights

Precision oncology requires accurate tumor identification for targeted cancer therapies. This review explores the evolution of targeted treatments, biomarker development, and challenges in implementing molecularly defined cancer subtypes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Targeted cancer therapies necessitate precise identification of susceptible tumors.
  • The development of targeted treatments has driven the classification of tumors into molecular subtypes.
  • Traditional tumor classifications are evolving towards molecularly defined subtypes.

Purpose of the Study:

  • To review the co-evolution of targeted therapies and biomarkers.
  • To examine current methods for identifying molecular tumor subtypes.
  • To discuss challenges and solutions for implementing precision oncology.

Main Methods:

  • Literature review of targeted therapies and biomarkers.
  • Analysis of current molecular subtype identification techniques.
  • Discussion of implementation challenges in precision oncology.

Main Results:

  • Paired evolution of targeted therapies and biomarkers is a key trend.
  • Various methods exist for molecular subtype identification.
  • Significant challenges impede the widespread adoption of precision oncology.

Conclusions:

  • Accurate biomarker-driven tumor identification is crucial for effective targeted therapy.
  • Overcoming implementation hurdles is essential for advancing precision oncology.
  • Continued research into molecular subtypes will refine cancer treatment strategies.
Keywords:
colon cancermolecular subtypesprecision oncology

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