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In Vitro Drug Dissolution: Alternative Methods01:17

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Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
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Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
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Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients,...
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Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
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In Vitro Dissolution of Na-Ca-P-Oxynitrides.

Natalia Anna Wójcik1,2, Polina Sinitsyna3, Sharafat Ali2

  • 1Advanced Materials Center, Institute of Nanotechnology and Materials Engineering, Gdańsk University of Technology, 11/12 G. Narutowicza Street, 80-233 Gdańsk, Poland.

Materials (Basel, Switzerland)
|December 10, 2021
PubMed
Summary

This study investigated sodium-calcium-phosphate oxynitride glasses in simulated body fluid. Nitrogen content influenced dissolution, decreasing mass loss, while niobate increased it, affecting pH.

Keywords:
bioactive glass-ceramicsin vitro dissolutionoxynitride glass-ceramicsimulated body fluid

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Area of Science:

  • Biomaterials science
  • Materials chemistry
  • Bioceramics

Background:

  • Sodium-calcium-phosphate oxynitride glasses and glass-ceramics are promising biomaterials.
  • Understanding their in vitro behavior is crucial for biomedical applications.

Purpose of the Study:

  • To investigate the in vitro dissolution of Mg, Si, and Nb-doped sodium-calcium-phosphate oxynitride glasses and glass-ceramics.
  • To analyze ion release and pH changes in simulated body fluid (SBF).

Main Methods:

  • Materials were immersed in SBF under static conditions for up to 7 days.
  • Ion release and pH changes were monitored.
  • The influence of nitrogen and niobate content on dissolution was assessed.

Main Results:

  • Nitrogen incorporation in homogenous glasses decreased mean mass loss.
  • Niobate incorporation increased mean mass loss.
  • Increased nitrogen content correlated with a rise in SBF pH.
  • Phosphate crystallites accelerated early-stage dissolution (up to 3 days).

Conclusions:

  • Nitrogen content significantly impacts the in vitro dissolution of these oxynitride glasses.
  • Niobate addition and nitrogen levels are key factors controlling material degradation and pH response in SBF.
  • The findings provide insights for designing tailored phosphate-based biomaterials.