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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Nociception01:44

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

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Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
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Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Related Experiment Video

Updated: Oct 10, 2025

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

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How Well Do Current Laboratory Biomarkers Inform Clinical Decision-Making in Chronic Pain Management?

Jonathan M Hagedorn1, Joshua Gunn2, Ryan Budwany3

  • 1Department of Anesthesiology and Perioperative Medicine, Division of Pain Medicine, Mayo Clinic, Rochester, MN, USA.

Journal of Pain Research
|December 10, 2021
PubMed
Summary
This summary is machine-generated.

Laboratory biomarkers show promise for identifying chronic pain patients at risk and predicting treatment response. Further research is needed to integrate these objective measures into routine clinical decision-making for pain management.

Keywords:
biomarkerschronic painoutcomes

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Spontaneous and Evoked Measures of Pain in Murine Models of Monoarticular Knee Pain
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Related Experiment Videos

Last Updated: Oct 10, 2025

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Development of Recombinant Proteins to Treat Chronic Pain
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Development of Recombinant Proteins to Treat Chronic Pain

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Area of Science:

  • Biomarkers in Medicine
  • Pain Management Research
  • Clinical Laboratory Science

Background:

  • Chronic pain diagnosis relies on subjective and objective criteria, lacking standardized laboratory biomarkers.
  • Current decision-making in chronic pain management is complex, integrating patient history, clinical exams, and treatment responses.

Purpose of the Study:

  • To conduct a literature review identifying and describing laboratory biomarkers for chronic pain management.
  • To assess the potential role of biomarkers in risk stratification and prognosis for chronic pain patients.

Main Methods:

  • A narrative review of existing literature on laboratory biomarkers in chronic pain.
  • Systematic literature search across PubMed, Science Direct, and Google Scholar databases.
  • Inclusion of 75 manuscripts analyzing biomarkers from urine, serum, cerebrospinal fluid, and saliva.

Main Results:

  • Identified specific laboratory biomarkers with potential utility in chronic pain management.
  • Evidence suggests biomarkers may predict disease development and progression.
  • Biomarkers show potential as prognostic indicators for treatment response in chronic pain.

Conclusions:

  • Specific biomarkers may aid in identifying at-risk chronic pain patients.
  • Biomarkers could serve as prognostic indicators for disease progression and treatment outcomes.
  • Additional research is required to validate biomarkers for clinical implementation in pain management.