Long-term ambient PM_2.5 exposure associated with cardiovascular risk factors in Chinese less educated population

Long-term exposure to ambient air pollution is related to major cardiovascular risk factors including diabetes, hypertension, hyperlipidemia and overweight, but with few studies in high-concentration nations like China so far. We aimed to investigate the association between long-term exposure to ambient fine particulate matter (particles with an aerodynamic diameter ≤ 2.5 μm, PM_2.5) and major cardiovascular risk factors in China.

Adult participants with selected biochemical tests were recruited from the Chinese Physiological Constant and Health Condition (CPCHC) survey conducted from 2007 to 2011. Gridded PM_2.5 data used were derived from satellite-observed data with adjustment of ground-observed data. District-level PM_2.5 data were generated to estimate the association using multivariate logistic regression model and generalized additive model.

A total of 19,236 participants from the CPCHC survey were included with an average age of 42.8 ± 16.1 years, of which nearly half were male (47.0%). The annual average PM_2.5 exposure before the CPCHC survey was 33.4 (14.8-53.4) μg/m³, ranging from 8.0 μg/m³ (Xiwuqi) to 94.7 μg/m³ (Chengdu). Elevated PM_2.5 was associated with increased prevalence of hypertension (odds ratio (OR) =1.022, 95% confidence interval (95%CI): 1.001, 1.043) and decreased prevalence of overweight (OR = 0.926, 95%CI: 0.910, 0.942). Education significantly interacted with PM_2.5 in association with all the interesting risk factors. Each 10 μg/m³ increment of PM_2.5 was associated with increased prevalence of diabetes (OR = 1.118, 95%CI: 1.037, 1.206), hypertension (OR = 1.101, 95%CI: 1.056, 1.147), overweight (OR = 1.071, 95%CI: 1.030, 1.114) in participants with poor education, but not in well-educated population. PM_2.5 exposure was negatively associated with hyperlipidemia in all participants (OR = 0.939, 95%CI: 0.921, 0.957). The results were robust in all the sensitivity analyses.

Association between long-term PM_2.5 exposure and cardiovascular risk factors might be modified by education. PM_2.5 was associated with a higher prevalence of diabetes, hypertension, and overweight in a less-educated population with time-expose dependency. Long-term exposure to PM_2.5 might be associated with a lower prevalence of hyperlipidemia.