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Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
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Flavivirus-host interactions: an expanding network of proviral and antiviral factors

William M Schneider1, Hans-Heinrich Hoffmann1

  • 1Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.

Current Opinion in Virology
|December 13, 2021
PubMed

Insights

Flaviviruses, transmitted by mosquitos and ticks, infect cells through complex interactions. Understanding these host-pathogen interactions, like the role of TMEM41B, can reveal new therapeutic targets for flavivirus infections.

Area of Science:

  • Virology
  • Cell Biology
  • Infectious Diseases

Background:

  • Flaviviruses are zoonotic pathogens posing a significant global health threat.
  • Transmission occurs via infected mosquitos and ticks.
  • Understanding cellular interactions is key to developing treatments.

Purpose of the Study:

  • To review recent literature on flavivirus-host cell interactions.
  • To identify novel therapeutic targets based on these interactions.
  • To highlight key host factors involved in flavivirus replication.

Main Methods:

  • Literature review of recent studies.
  • Focus on low-bias methods for interaction discovery (protein-protein, protein-RNA, genetic).
  • Characterization of host protein TMEM41B.

Main Results:

  • Identification of critical host-pathogen interactions.
  • TMEM41B is essential for infection by various flaviviruses and coronaviruses.
  • Low-bias methods facilitate discovery of new interaction networks.

Conclusions:

  • Understanding flavivirus cellular interactions is crucial for therapeutic development.
  • TMEM41B represents a significant host factor for multiple viral infections.
  • Continued research into host-pathogen interactions will yield novel intervention strategies.

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