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Updated: Oct 10, 2025

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
Model Integration: Can Understanding Biopsychosocial Gut-Brain Axis Mechanistic Pathways Improve our Clinical
Shannon H Ford1, Eric A Hodges2, Suzanne Thoyre2
1UNCG School of Nursing, 237 McIver Street, Greensboro, NC 27402.
Introduction:
Most NPs practice in primary care settings. Cognitive tools to inform and advance NP understanding of biopsychosocial mechanisms can support early recognition, interdisciplinary collaboration, interventions, and prevention of negative outcomes.
Theory And Methods:
We describe the development of a model to support NP consideration of gut-brain axis (GBA) evidence-based pathways, contributing variables, and related health outcomes.
Results:
The model's outcomes are factors associated with homeostasis or disruption of biological, psychological, and social systems.
Discussion/Conclusion:
This cognitive tool aims to support NP awareness of multi-domain GBA relationships to consider with differential diagnoses and clinical treatment of the "whole body system".
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