![Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F61682.jpg&w=3840&q=50)
An electrochemical sensor based on a Co3O4-ERGO nanocomposite modified screen-printed electrode for detection of uric
Gizem Turkkan1, Salih Zeki Bas1, Keziban Atacan2
1Department of Chemistry, Selcuk University, 42250, Konya, Turkey. musozmen@gmail.com.
Abstract:
In this study, we report the fabrication of a nanocomposite consisting of Co3O4 nanoparticles (Co3O4 NPs) and electrochemically reduced graphene oxide (ERGO) on a screen-printed electrode (SPE) and its sensing performance in the electrochemical detection of uric acid (UA). The surface modification of the electrode was confirmed by using a variety of characterization techniques (FE-SEM, XRD, AFM, EDX, WCA, FTIR, and Raman spectroscopy). In addition, the surface modification was electrochemically characterized step by step through CV, EIS and DPV techniques, and the results showed that the Co3O4-ERGO nanocomposite exhibited highly sensitive and selective sensing performance towards the oxidation of UA in 0.1 M (pH 7.0) phosphate buffer solution (PBS). The sensor (Co3O4-ERGO/SPE) signals were observed to be linear to the UA concentration in the range of 5 μM to 500 μM (R2 = 0.9985). After revealing its other performance characteristics, such as repeatability, reproducibility, stability, sensitivity, and selectivity, the sensor was successfully applied to the analysis of UA in artificial saliva samples.
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